Apoptotic activity of substituted 3-O-acetyl-betulinic acid benzylamides
نویسندگان
چکیده
Acetylated betulinic acid ( BA ) was converted into mono-substituted benzylamides 2 – 14 . Screening in SRB assays showed them as cytotoxic for a variety of different human tumor cell lines. While parent not within the limits assay (cut-off 30 μM), target amides were cytotoxic. Their bioactivity well their cell/non-tumor selectivity depended on substitution pattern aromatic ring. The most active compound 9 (holding an ortho methoxy substituent) acted mainly by apoptosis. • Mono-substituted prepared from acid. These conjugates subjected to cytotoxicity assays. held good several An ortho-methoxy substituted acting
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ژورنال
عنوان ژورنال: European journal of medicinal chemistry reports
سال: 2021
ISSN: ['2772-4174']
DOI: https://doi.org/10.1016/j.ejmcr.2021.100016